Lives listing with initial: S
- Secker, Reverend Thomas, archbishop of Canterbury (born 1693–died 1768), English churchman
- Secondat, Charles Louis de, baron de Montesquieu (born 1689–died 1755), French magistrate, philosopher, academician
- Secousse, Daniel François (born 1691–died 1754), French author, historian, academician
- Sedaine, Michel Jean (born 1719–died 1797), French author, playwright, academician
- Sedgwick, Reverend Adam (born 1785–died 1873), English geologist, university teacher, academician
- Sedgwick, Edward (flourished 1764), English lawyer, civil servant
- Sedgwick, Pamela Dwight (born c. 1753–died 1807), American home-maker
- Sedgwick, Theodore (born 1746–died 1813), American judge, politician
- Seele, George (born c. 1728–died 1810), English schoolteacher, churchman
- Sefond, — de [née Mesnard de Conichard] (flourished 1784), French home-maker
- Segar, John (born 1730), American [unknown occupation]
- Séguier, Anne Jacqueline Charlotte (born 1696), French home-maker
- Séguier, Jean François (born 1703–died 1784), French archaeologist, epigraphist, astronomer, botanist, academician
- Séguier, Sidoine Charles François, marquis de Saint-Brisson (born 1738–died 1773), French army officer, author
- Ségur, Louis Philippe de, comte de Ségur (born 1753–died 1830), French diplomat, politician, author, poet
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