Lives listing with initial: S
- Scudamore, John, 1st Viscount Scudamore (born 1601–died 1671), English courtier, politician, member of Parliament, army officer, royalist
- Scudamore, Sophia [née Westcomb] (born after 1722), English home-maker
- Scurlock, Alexander (born 1695–died 1770), Welsh gentleman
- Scurlock, Reverend David (born 1694–died 1793), Welsh churchman, author
- Scurlock, Elizabeth [née Still] (died 1713), English home-maker
- Scurlock, John (died 1715), Welsh mercer, politician, tradesman
- Scurlock, Jonathan (born 1693–died 1722), Welsh gentleman
- S. E. (flourished c. 1735), English [unknown occupation]
- Seabring, — (flourished 1789), American landlady
- Seagrove, James (born c. 1747–died 1812), American [unknown occupation]
- Seaman, Reverend William (born 1607–died 1680), English churchman, Orientalist, translator
- Seamer, James (born c. 1657–died 1739), English goldsmith, businessman, jeweller, banker, author
- Searle, George (born c. 1751–died 1796), American [unknown occupation]
- Searle, James (born 1733–died 1797), American [unknown occupation]
- Sebastian, Benjamin (born 1745–died 1834), American [unknown occupation]
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