Lives listing by nationality: English
- Saunderson, Doctor Nicholas (born 1683–died 1739), English mathematician
- Savage, Richard (born 1697–died 1743), English author, playwright
- Savile, George, 1st marquess of Halifax (born 1633–died 1695), English politician, author
- Savile, Sir George (born 1726–died 1784), English politician, member of Parliament
- Scarburgh, Sir Charles (born 1615–died 1694), English physician, scientist
- Scobell, Henry (born 1610–died 1660), English legal author, author
- Scoresby, Reverend William (born 1789–died 1857), English churchman, scientist, academician
- Scott, Elizabeth, duchess of Buccleuch [née Montagu] (born 1743–died 1827), English aristocrat
- Scott, John (born 1730–died 1783), English author, poet
- Scott, John, 1st earl of Eldon (born 1751–died 1838), English lawyer, politician, member of Parliament
- Scott, Sarah [née Robinson] (born 1723–died 1795), English author, novelist
- Scott, Sir William, Baron Stowell (born 1745–died 1836), English academic, lawyer, judge, politician, member of Parliament
- Scriblerus Club (founded 1713), English literary club
- Scudamore, John, 1st Viscount Scudamore (born 1601–died 1671), English courtier, politician, member of Parliament, army officer, royalist
- Scudamore, Sophia [née Westcomb] (born after 1722), English home-maker
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