Lives listing with initial: S
- Spencer, John Charles, 3rd Earl Spencer (born 1782–died 1845), English politician, member of Parliament, sportsman, agriculturalist
- Spencer, Nicholas (died 1689), English merchant, politician, civil servant, governor
- Spens, George (flourished c. 1679), Scottish [unknown occupation]
- Spierin, Reverend George W. (flourished c. 1797), American churchman
- Spon, Doctor Jacob (born 1647–died 1685), French Huguenot, physician, antiquarian, archaeologist, author, historian, travel-writer, historian
- Spooner, Ephraim (born 1735–died 1818), American [unknown occupation]
- Spotsylvania County, a friend in (flourished 1789), American [unknown occupation]
- Spottiswoode, John [junior] (born 1711–died 1793), Scottish laird
- Spottiswoode, John (born 1741–died 1805), Scottish lawyer
- Spranger, Edward (flourished 1691–1704), English lawyer
- Spreat, John (flourished 1675–1704), English servant
- Spring, Seth (flourished 1789), American soldier, landowner
- Srinivasa Iyengar, Kodaganallur Ramaswami (born 1908–died 1999), Indian author, academic, university administrator
- Staal, Marguerite Jeanne de, baronne de Staal [née Cordier de Launay] (born 1684–died 1750), French author, writer of memoirs
- Stadnitski, Pieter (flourished 1789), Dutch financier, banker
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