Lives listing with initial: S
- Sömmerring, Doctor Samuel Thomas von (born 1755–died 1830), German physician, anatomist, anthropologist, palaeontologist, inventor
- Somodevilla y Bengoechea, Zenón de, marqués de la Ensenada (born 1702–died 1781), Spanish aristocrat, statesman, civil servant, naval officer
- Sonnemans, Mattheus (flourished c. 1696), Dutch [unknown occupation]
- Sonnenberg, Gottfried von (flourished 1684–1685), German alchemist
- Sophia Albertina, princess of Sweden (born 1753–died 1829), Swedish aristocrat, princess
- Sophia Dorothea, queen consort of Prussia (born 1687–died 1757), German princess, consort
- Sophia Magdalena, queen consort of Sweden (born 1746–died 1813), Swedish consort
- Princess Sophia Matilda, of Gloucester (born 1773–died 1844), English aristocrat
- Sorbière, Samuel (born 1615–died 1670), French physician, astronomer, tutor, academician, executor
- Soret, Jean (born 1710), French lawyer, newspaper editor
- Souchu de Rennefort, René (flourished 1774–1789), French lawyer
- Soulas, père Léonor Jean Christin, abbé d’Allainval (born c. 1700–died 1753), French churchman, author, playwright
- Soulavie, Jean Louis Giraud (born 1752–died 1813), French politician, revolutionary, diplomat, author
- Soullier, Étienne (flourished c. 1762), [unknown nationality & occupation]
- Sourdeval, Claude Antoine François de (born 1729–died 1795), French naval official
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