Lives listing with initial: S
- Silva y Álvarez de Toledo, Fernando de, duque de Alba (born 1714–died 1776), Spanish army officer, diplomat, patron
- Silver, George (flourished 1802), [unknown nationality & occupation]
- Silvester, David (born 1742–died 1798), American [unknown occupation]
- Silvester, Francis (born 1767–died 1845), American [unknown occupation]
- Silvester, Jane (flourished 1789), American home-maker
- Silvester, Peter (born 1734–died 1808), American politician
- Silvestre, Abraham Jacques (died 1765), French notary
- Silvestre, Jean Antoine (flourished c. 1766), Swiss activist
- Simcoe, John Graves (born 1752–died 1806), English army officer, colonial administrator, politician, member of Parliament
- Simolin, Ivan Matveyevich (born 1720–died 1799), Russian diplomat
- Simon, M. — (flourished c. 1756), French [unknown occupation]
- Simon, M. — (flourished c. 1768), French wine-merchant, tradesman
- Simon, Richard (born 1638–died 1712), French biblical scholar, theologian, author
- Simonde de Sismondi, Jean Charles Léonard (born 1773–died 1842), Swiss politician, economist, political philosopher, university teacher
- Simonds, Jonas (died c. 1816), American [unknown occupation]
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