Lives listing by occupation: politician
- Snyder, Simon (born 1759–died 1819), American politician
- Somers, John, 1st Baron Somers (born 1651–died 1716), English lawyer, politician, member of Parliament, civil servant, academician
- Somerville, Sir James, baronet (born c. 1698–died 1748), Irish gentleman, politician, member of Parliament
- Soulavie, Jean Louis Giraud (born 1752–died 1813), French politician, revolutionary, diplomat, author
- Sousa Coutinho, Domingos António de, 1st marquis of Funchal (born 1760–died 1833), Portuguese aristocrat, diplomat, politician, colonial governor
- Southwell, Edward (born 1671–died 1730), English civil servant, government minister, politician, member of Parliament
- Southwell, Sir Robert (born 1635–died 1702), Irish diplomat, civil servant, academician, politician, member of Parliament
- Southworth, Constant (born 1730–died 1813), American politician
- Spencer, Charles, 3rd earl of Sunderland (born 1675–died 1722), English aristocrat, politician
- Spencer, Charles, 3rd duke of Marlborough (born 1706–died 1758), English aristocrat, politician, army officer
- Spencer, George John, 2nd Earl Spencer (born 1758–died 1834), English politician, bibliophile, collector, academician
- Spencer, John, 1st Earl Spencer (born 1734–died 1783), English aristocrat, patron, collector, politician, member of Parliament
- Spencer, John Charles, 3rd Earl Spencer (born 1782–died 1845), English politician, member of Parliament, sportsman, agriculturalist
- Spencer, Nicholas (died 1689), English merchant, politician, civil servant, governor
- Stanhope, James, 1st Earl Stanhope (born 1673–died 1721), English army officer, diplomat, politician, member of Parliament
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