Lives listing by occupation: politician
- Saint Quintin, Sir William, 3rd baronet (born 1662–died 1723), English politician, member of Parliament, civil servant
- Saladin d’Onex, Jean Louis (born 1701–died 1784), Swiss diplomat, politician
- Sandoz de Rosières, François (born 1692–died 1779), Swiss aristocrat, politician
- San Martín, José de (born 1778–died 1850), Argentinian army officer, politician
- Sarotti, Paolo (born 1633–died after 1689), Italian politician, diplomat, scientist, academician
- Sartine, Antoine Raymond Jean Gualbert Gabriel de, comte d’Albi (born 1729–died 1801), French aristocrat, politician, civil servant, spymaster
- Saunders, John [junior] (born c. 1724–died 1797), American politician
- Sauvage de Verny, Jacques Philibert de (flourished c. 1760), French politician
- Savile, George, 1st marquess of Halifax (born 1633–died 1695), English politician, author
- Savile, Sir George (born 1726–died 1784), English politician, member of Parliament
- Schaak, Peter van (flourished 1767–1800), American politician
- Scheffer, Greve Carl Fredrik (born 1715–died 1786), Swedish politician, academician
- Scheffer, Greve Ulric (born 1716–died 1799), Swedish army officer, diplomat, prime minister, politician, member of Parliament
- Schmid, Georg Ludwig (born 1720–died 1805), Swiss diplomat, politician, legal author
- Schudt, Bernhard Jacob (born 1710–died 1785), German lawyer, politician
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