Lives listing by occupation: politician
- Onslow, Arthur (born 1691–died 1768), English politician, member of Parliament
- Onslow, George, 1st earl of Onslow (born 1731–died 1814), English politician, member of Parliament
- Onslow, Thomas, 2nd Baron Onslow (born 1679–died 1740), English aristocrat, politician, member of Parliament, civil servant, landowner
- Orde, Thomas (born 1746–died 1807), English politician, member of Parliament
- Orlandos, Ioannis (born c. 1770–died 1852), Greek ship-owner, politician, revolutionary
- Orléans, Louis Philippe Joseph d’, duc d’Orléans (born 1747–died 1793), French aristocrat, politician, revolutionary
- Ormesson de Noiseau, Anne Louis François de Paule Lefevre d' (born 1753–died 1794), French librarian, politician
- Osborne, Francis, 5th duke of Leeds (born 1751–died 1799), English aristocrat, government minister, politician, member of Parliament
- Osborne, Thomas, 1st duke of Leeds (born 1632–died 1712), English politician, member of Parliament
- Osgood, Joshua Bailey (born 1753–died 1791), American merchant, landowner, politician
- Ostervald, Samuel (born 1692–died 1769), Swiss politician, legal author
- Osterwald, Frédéric Samuel (born 1713–died 1795), Swiss publisher, politician
- Oswald of Dunnikier, James (born 1715–died 1769), Scottish politician, member of Parliament, lawyer, civil servant
- Otis, Samuel Allyne (born 1740–died 1814), American merchant, politician
- Otto, Louis Guillaume (born c. 1753–died 1817), French politician, diplomat
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