Lives listing by nationality: American
- Scott, Thomas (born 1739–died 1796), American politician
- Scriba, George Ludwig Christian (born 1753–died 1836), American [unknown occupation]
- Seabring, — (flourished 1789), American landlady
- Seagrove, James (born c. 1747–died 1812), American [unknown occupation]
- Searle, George (born c. 1751–died 1796), American [unknown occupation]
- Searle, James (born 1733–died 1797), American [unknown occupation]
- Sebastian, Benjamin (born 1745–died 1834), American [unknown occupation]
- Sedgwick, Pamela Dwight (born c. 1753–died 1807), American home-maker
- Sedgwick, Theodore (born 1746–died 1813), American judge, politician
- Segar, John (born 1730), American [unknown occupation]
- Senators absent (appears in EE c. 1789), American political group
- Senators present (appears in EE c. 1789), American political group
- Seney, Joshua (born 1756–died 1798), American lawyer, politician
- Senter, Isaac (born 1753–died 1799), American [unknown occupation]
- Sewall, David (born 1735–died 1825), American lawyer, judge
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