Lives listing by nationality: Swiss
- Schinz, Johann Rudolf (born 1745–died 1790), Swiss churchman, Protestant, agriculturalist
- Schmid, Georg Ludwig (born 1720–died 1805), Swiss diplomat, politician, legal author
- Schulthess, Jonathan (born 1744–died 1830), Swiss [unknown occupation]
- Seigneux, Gabriel de, seigneur de Correvon (born 1695–died 1775), Swiss politician, translator
- Selapris, Jacques [née Jakob Schlappritzi] (pseudonym/initials used until 1681), Swiss banker
- Sellon, Jean François (born 1707–died 1790), Swiss diplomat
- Sénébier, Jean (born 1742–died 1809), Swiss churchman, Protestant, librarian, historian, archivist
- Silvestre, Jean Antoine (flourished c. 1766), Swiss activist
- Simonde de Sismondi, Jean Charles Léonard (born 1773–died 1842), Swiss politician, economist, political philosopher, university teacher
- Sinner, Johann Rudolf (born 1730–died 1787), Swiss librarian, medievalist, archivist
- Société Rousseau (active c. 1779), Swiss trading firm
- Spanheim, Ezechiel von, Freiherr von Spanheim (born 1629–died 1710), Swiss diplomat, scholar, classicist, numismatist
- Steiger, Niklaus Friedrich, baron de Montricher (born 1729–died 1799), Swiss civil servant, magistrate, counter-revolutionary
- Stürler, Johann Rudolf (born 1701–died 1777), Swiss politician
- Stürler, Karl (born 1711–died 1793), Swiss politician
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