Lives listing by nationality: Scottish
- Sharp, Buccleuch (flourished c. 1786), Scottish printer
- Sharpe, Reverend John (born 1680–died 1713), Scottish churchman
- Sharpe, Matthew (born 1693–died 1769), Scottish landowner
- Sibbald, James (flourished 1821–1822), Scottish hoaxer
- Sibbald Scott, Sir David (born 1782), Scottish merchant
- Simson, Robert (born 1687–died 1768), Scottish university teacher, mathematician
- Sinclair, Sir John, 1st Baronet Sinclair of Ulbster (born 1754–died 1835), Scottish agriculturalist, politician, member of Parliament
- Skene, Andrew (born 1703–died 1767), Scottish physician, surgeon
- Skene, David (born 1731–died 1770), Scottish naturalist, physician, midwife, academician
- Skene, George (born 1740–died 1803), Scottish philosopher, historian
- Skene, Robert (born 1719–died 1787), Scottish army officer, soldier, politician, member of Parliament
- Smith, Mr — (flourished c. 1759), Scottish companion
- Smith, Adam (born 1711–died after 1754), Scottish Customs official, civil servant
- Smith, Adam (born 1723–died 1790), Scottish philosopher, political economist, university teacher, academician
- Smith, John (flourished 1751–1766), Scottish mathematician
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