Lives listing by nationality: Irish
- Southwell, Robert (born 1608–died 1677), Irish landowner, civil servant
- Southwell, Sir Robert (born 1635–died 1702), Irish diplomat, civil servant, academician, politician, member of Parliament
- Stanhope, Leicester Fitzgerald Charles, 5th earl of Harrington (born 1784–died 1862), Irish army officer, pamphleteer
- Stannard, Eaton (born 1685–died 1755), Irish lawyer, politician, member of Parliament
- Stapleton, Sir William, 1st Baronet Stapleton (died 1686), Irish soldier, army officer, colonial governor, plantation-owner
- Staunton, Sir George Leonard, baronet (born 1737–died 1801), Irish physician, plantation-owner, diplomat, East India Company official, academician
- Staunton, Thomas (flourished 1711–1732), Irish lawyer
- Stearne, Reverend John, bishop of Clogher (born 1660–died 1745), Irish churchman, philanthropist
- Steele, Richard (born 1672–died 1729), Irish author, journalist, politician
- Sterne, Laurence (born 1713–died 1768), Irish churchman, novelist
- Stewart, Robert, Viscount Castlereagh (born 1769–died 1822), Irish politician, member of Parliament
- Stewart, William, 1st earl of Blessington (born 1709–died 1769), Irish aristocrat
- St Lawrence, Lucy, Baroness Howth [née Gorges] (born c. 1711), Irish aristocrat
- St Lawrence, William, 14th Baron Howth (born 1688–died 1748), Irish politician, member of Parliament, aristocrat
- Sulivan, Laurence (born c. 1713–died 1786), Irish merchant, East India Company official, colonial governor
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