Lives listing by nationality: German
- Schudt, Bernhard Jacob (born 1710–died 1785), German lawyer, politician
- Schulenburg, Ehrengarde Melusina von der, baroness von der Schulenburg, duchess of Kendal (born 1667–died 1743), German aristocrat
- Schulenburg, Johann Matthias von, graf von Schulenburg (born 1661–died 1747), German aristocrat, army officer, patron
- Schulze, Johann Heinrich (born 1687–died 1744), German university teacher, polymath
- Schumacher, Heinrich Christian (born 1780–died 1850), German astronomer, surveyor, academician
- Schütz, Christian Gottfried (born 1747–died 1832), German humanist, scholar
- Schweigger, Georg Wilhelm (flourished c. 1753), German banker
- Senate of Bremen (founded c. 1186), German government department
- Senckenberg, Johann Erasmus von (born 1717–died 1795), German lawyer
- Seyffer, Karl Felix von (born 1762–died 1822), German astronomer
- Söldner, M. — (flourished c. 1757), German business clerk
- Solomon, Johann Peter (born 1745–died 1815), German composer, violinist, musician, impresario
- Sömmerring, Doctor Samuel Thomas von (born 1755–died 1830), German physician, anatomist, anthropologist, palaeontologist, inventor
- Sonnenberg, Gottfried von (flourished 1684–1685), German alchemist
- Sophia Dorothea, queen consort of Prussia (born 1687–died 1757), German princess, consort
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