Lives listing by nationality: American
- Clymer, George (born 1739–died 1813), American merchant, politician
- Cobb, David (born 1748–died 1830), American [unknown occupation]
- Cobb, Matthew (born 1757–died 1824), American [unknown occupation]
- Cochrane, Robert (born c. 1735–died 1824), American [unknown occupation]
- Cocke, — (flourished 1767), American home-maker
- Cockle, John (flourished 1789), American [unknown occupation]
- Coffin, Edmund (flourished 1789), American sea captain, civil servant
- Cogswell, James (born 1746–died 1792), American surgeon
- Collin, Nicholas (born 1746–died 1831), American [unknown occupation]
- Collins, Cornelius (died c. 1791), American [unknown occupation]
- Collins, Isaac (born 1746–died 1817), American printer, publisher, bookseller, merchant
- Collins, Stephen (born 1733–died 1794), American Quaker, merchant
- Collins, Thomas (born 1732–died 1789), American [unknown occupation]
- Colt, Peter (born 1744–died 1824), American businessman, politician
- The Columbian Herald (founded 1784), American newspaper
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