Letter listing for 1680–1689
- Robert Boyle to Reverend Thomas Barlow, bishop of Lincoln, 24 January–2 December 1686
- James Tyrrell to John Locke, 30 January 1686
- William Charleton to John Locke, 5 February 1686
- Marcello Malpighi to padre Carlo Antonio Ronchi, 6 February 1686
- John Locke to Edward Clarke, 8 February 1686
- Instructions for the education of Edward Clarke's children by John Locke, c. 8 February 1686
- Sir John Perceval, baronet to Robert Boyle, 12 February 1686
- Thomas Mackrith to Robert Boyle, 15 February 1686
- Poem by Lady Damaris Masham [née Cudworth], c. March 1686
- James Dalrymple, 1st Viscount Stair to Robert Boyle, 12 March 1686
- Edmond Halley to Anton van Leeuwenhoek, 12 March 1686
- Sir Paul Rycaut to Robert Boyle, 13 March 1686
- John Locke to Edward Clarke, 15 March 1686
- John Locke to Edward Clarke, 15 March 1686
- conte Luigi Ferdinando Marsigli to Robert Boyle, 20 March 1686
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